Review · Oral health

DentaTonic review: an enzyme tablet checked against the research

DentaTonic packs ten ingredients, mostly enzymes and milk proteins, into a single 400 mg tablet. Two of them have been tested together in real tablet trials. The rest of the story is harder to check, and the label does not help.

By Grant Whitaker, Editor · Updated October 23, 2026 · 15 studies checked on PubMed

What DentaTonic is

DentaTonic is a chewable-style tablet distributed by a company of the same name in Tallmadge, Ohio, according to its label. It is sold on its official website through Digistore24 in 1, 3 and 6-bottle packages. Each bottle holds 30 tablets, one a day. The label suggests letting the tablet melt in the mouth for several seconds or swallowing it with a glass of water.

The sales page calls it a "Dental Filtration Breakthrough." Its story is that an enzyme in saliva, lactoperoxidase, filters harmful bacteria, that its levels drop with age, and that hydrogen cyanide from food and mouth bacteria weakens it. The tablet is presented as a way to replenish it.

What is on the label

We read the Supplement Facts panel shown on the official site. The vendor's affiliate page does not grant permission to reproduce its images, so we describe the label in words; you can view it on the official website.

• Proprietary Blend, 400 mg: guava fruit powder, microcrystalline hydroxyapatite complex, beta-glucanase, dextranase, amylase, lactoperoxidase, glucose oxidase, amyloglucosidase, lysozyme, lactoferrin.
• Other ingredients: xylitol, microcrystalline cellulose, magnesium stearate, natural flavoring.

No individual amounts are given. Ingredients in a blend are listed by weight, largest first, so guava fruit powder is the biggest component and lactoferrin is the smallest. That ordering matters, because lactoferrin is the ingredient with the most direct human research.

The sales page lists seven ingredients. Guava fruit powder, glucose oxidase and amyloglucosidase appear on the label but not on the page. That omission matters, because glucose oxidase is the enzyme that makes the hydrogen peroxide lactoperoxidase needs to work ^[12].

The formula next to the research

For each ingredient we looked for human trials on teeth, gums or breath, and compared how the ingredient was given in those trials with how DentaTonic delivers it.

Lactoferrin and lactoperoxidase: the part with real trials

Lactoferrin and lactoperoxidase are proteins that occur naturally in saliva and milk. A Japanese dairy company, Morinaga Milk Industry, has run several placebo-controlled trials of tablets combining the two, and its researchers are authors on all of the studies below. That does not make the results wrong, but it is worth knowing.

• Gum health in healthy adults: 150 adults took a high-dose tablet (60 mg lactoferrin, 7.8 mg lactoperoxidase a day), a low-dose tablet (a third of that) or placebo for 12 weeks. Only the high-dose group showed a gingival index reduction that beat placebo. Both doses lowered plaque scores against baseline, and 109 people were in the final analysis ^[1].
• Older adults: 46 older people, most living in nursing homes, sucked on a tablet after every meal for 8 weeks. Bacterial counts on the tongue and in plaque fell compared with baseline, and one gum-related bacterium fell more than with placebo ^[2]. A follow-up analysis of the same group found the mix of mouth bacteria shifted ^[3].
• Breath: in two small crossover trials (15 and 39 people), a single tablet lowered measured sulfur compounds in mouth air compared with placebo, measured 10 minutes to 2 hours later ^{[5] [4]}.
• A trial with no difference: 72 adults with chronic periodontitis took the tablets or a control tablet daily for 12 weeks. Gum measurements and bacteria were similar in both groups, and the authors described the effect as possibly weak ^[6].

Two details matter for DentaTonic. First, the effect on gums appeared at the higher dose and not the lower one, so the amount counts, and DentaTonic does not tell us its amount. Second, the older-adult trial used three tablets a day. DentaTonic is one tablet a day.

Enzyme toothpastes: good results, different product

Much of the modern research on these enzymes comes from fluoride toothpastes that contain lactoperoxidase, glucose oxidase, lysozyme and lactoferrin. In a 26-week trial of 251 adults in China, a toothpaste of this type improved gum and plaque scores more than a regular fluoride toothpaste; most authors were employed by the toothpaste maker ^[7]. Studies from the same company found these toothpastes raised hydrogen peroxide and lysozyme levels in users' saliva ^[8], and an independent Swiss study found enzyme toothpaste slurries reduced plaque and gum bleeding compared with rinsing with water in a short no-brushing test ^[9].

These results come from brushing twice a day with a paste that coats the teeth. They do not tell us what a once-daily tablet does, and we found no trial of DentaTonic itself.

Hydroxyapatite: studied as toothpaste

Hydroxyapatite is the mineral that makes up most of tooth enamel. A 2024 meta-analysis found that hydroxyapatite toothpastes, mouthwashes and gels performed better than placebo on caries-related outcomes, and two authors worked for a hydroxyapatite toothpaste maker ^[10]. Every study in that review applied hydroxyapatite directly to the teeth in a paste or rinse. We found none using a tablet, and the amount in DentaTonic is unknown.

Dextranase and the starch enzymes

Dextranase breaks down dextran, a sticky sugar some mouth bacteria use to build plaque. A University of Pennsylvania team showed that dextranase combined with other enzymes, delivered from a chewing gum tablet, broke up biofilms in the lab ^[11]. We did not find human trials of dextranase, beta-glucanase, amylase or amyloglucosidase taken as a supplement for teeth or gums.

What the marketing says vs. what we could verify

"Lactoperoxidase levels drop as you age." We searched PubMed for studies of salivary peroxidase and age and did not find one supporting this as stated. We could not verify it.

"Hydrogen cyanide weakens the enzyme." The published chemistry points in a different direction. Lactoperoxidase uses hydrogen peroxide to convert thiocyanate into antibacterial compounds ^[12], and the body makes much of its salivary thiocyanate from cyanide; smokers, for example, have about three times more of it in saliva ^[13]. We found no study showing that dietary or bacterial cyanide weakens salivary lactoperoxidase.

"Speeds up the regeneration of teeth and gums" (affiliate page). We found no research showing that any DentaTonic ingredient taken as a tablet does this.

The reference page. The official site has a "Scientific References" page. When we checked it, the sources were about skin: cucumber extract, aloe vera wound healing, a skin peptide, hyaluronan in skin and wrinkles in Shar Pei dogs. None concerned teeth, gums or any DentaTonic ingredient. It appears to belong to a different product.

"Designed for all ages and medical conditions" (FAQ). The label itself tells people under 18, pregnant or nursing women and anyone with a medical condition to talk to a physician first. We go with the label.

Price, packages and refund policy

One bottle lasts 30 days. Prices on the official site when we checked:

• 6 bottles: $49 each ($294 total), free US shipping, two digital guides included. About $1.63 a day.
• 3 bottles: $59 each ($177 total), free US shipping, two digital guides included.
• 1 bottle: $69, free US shipping.

Shipping to Canada, the UK, Ireland, Australia and New Zealand is listed at $15.95. The FAQ describes every order as a one-time payment with no autoship.

The refund policy gives you 60 days from delivery. You must email support and mail back all the bottles, empty or not, and return shipping is at your expense. One oddity: the same refund page suggests using the product for at least three months before deciding, which is longer than the 60-day window. If you want to judge it the way the 12-week trials did, you would need to ask for a refund before you reach that point.

Safety

In the lactoferrin and lactoperoxidase tablet trials, researchers reported no adverse reactions linked to the tablets, and other side effects were similar to placebo ^[1]. Those trials were small and short, so they cannot rule out rarer problems.

The main concern we found is allergy. Lysozyme is commonly made from hen's egg white, and doctors have reported a severe allergic reaction to a 20 mg lysozyme lozenge in a child with egg allergy, noting that people with egg allergy often do not realize lysozyme can be a problem ^[15]. Lactoferrin, lactoperoxidase and lysozyme used in oral care products have typically been purified from cow's milk ^[14]. The DentaTonic label does not state the source of any of them, so if you have an egg or milk allergy, check with the seller and your doctor before taking it.

We did not find published reports of drug interactions for these enzymes or proteins on PubMed. That mostly reflects how little they have been studied as supplements, so the lack of reports should not be read as proof of safety. Talk to your doctor before starting DentaTonic if you take prescription medication or have a medical condition. Results vary from person to person, and new or worsening symptoms in your mouth or anywhere else deserve medical care.

What we liked and what gave us pause

Frequently asked questions

Where can I buy DentaTonic?

On the official DentaTonic website, with checkout handled by Digistore24. The vendor does not allow listings on Amazon, eBay or similar marketplaces, so products found there may not be genuine or covered by the refund policy.

Can DentaTonic replace brushing, flossing or dental visits?

No. Every trial we found tested these ingredients alongside normal oral hygiene, and the enzyme toothpaste trials used them inside a fluoride toothpaste. Keep brushing, flossing and seeing your dentist.

How long before I notice anything?

Results vary. The gum trials ran 8 to 12 weeks, while the breath trials measured effects within two hours of a single tablet. Keep the 60-day refund window in mind if you plan a longer test.

Does it contain sugar?

The label lists xylitol as a sweetener and no sugar. The amount of xylitol is not stated.

Is it safe if I have an egg or milk allergy?

We cannot say. Lysozyme and lactoferrin are commonly sourced from egg and milk, and the label does not state the source. Ask the seller and your doctor first.

How we reviewed DentaTonic

We read the official sales page, refund policy, reference page, affiliate page and Supplement Facts label, then searched PubMed for human trials of each ingredient on teeth, gums and breath. We compared how each ingredient was given in those trials with what the label discloses. We did not test the product on people, and nobody at Stark Verve is a dentist or medical professional. Read our editorial policy to learn how we choose and update reviews. Stark Verve earns a commission if you buy through our links; that never changes what we write about the evidence.