Review · Nerve health

Arialief review: what one 575 mg capsule can and cannot hold

Arialief is a once-a-day capsule sold for nerve comfort in the feet and hands. It lists six ingredients, several with genuine human research. The problem is arithmetic: the capsule is far too small for the doses those studies used.

By Grant Whitaker, Editor · Updated October 31, 2026 · 15 studies checked on PubMed

What Arialief is

Arialief is a capsule supplement sold on its own website, arialief.com, and through a ClickBank version of the same sales page. The label says "Distributed by Arialief" with a support email, carries the word "Mioralab" above the product name, and calls the product "nutritional support for nerve health." The serving is one capsule a day, 30 capsules per bottle. It is sold in 2, 3 and 6-bottle packages as a one-time purchase.

The sales page frames Arialief around nerve discomfort in the feet and hands, uses strong disease language in its headlines, and promises fast and long-lasting relief. We set those claims aside and looked at what the label actually contains.

The label, and the math problem

The Supplement Facts panel lists one quantified nutrient and one blend:

• Magnesium, 80 mg (19% of the Daily Value), "as magnesium glycinate from proprietary blend."
• Proprietary blend, 575 mg: magnesium glycinate, alpha lipoic acid, butcher's broom root extract, L-carnitine, turmeric rhizome extract (95% curcuminoids) and coenzyme Q10 as ubiquinone. No individual amounts.

Here is why that matters. The magnesium glycinate that supplies the 80 mg of magnesium sits inside the 575 mg blend. Magnesium is only part of the weight of magnesium glycinate. In the pure compound (magnesium bisglycinate, molecular weight about 172, of which magnesium is about 24) it is roughly 14% of the weight, so 80 mg of magnesium would need around 570 mg of the compound. That would leave only a few milligrams for the other five ingredients combined. Some commercial magnesium glycinate is buffered with other magnesium salts and is richer in magnesium, which would free up more space, but the label does not say which form is used.

Even in the most generous case you can imagine, where the magnesium weighed nothing at all, the other five ingredients would share at most 495 mg. The single most studied ingredient here, alpha lipoic acid, was tested at 600 mg a day by itself. So the label settles the dosing question without any guesswork about the blend: Arialief cannot contain the studied amount of its best-researched ingredient, let alone the studied amounts of the rest.

The formula next to the research

Most of the trials below enrolled adults with diabetes and nerve damage in the feet (diabetic polyneuropathy). That is the population where these nutrients have been tested most. We report them as studied; none of it means Arialief has been tested in anyone.

Alpha lipoic acid: the strongest ingredient, at an unknown dose

Alpha lipoic acid is an antioxidant with the most consistent human data in this area. In SYDNEY 2, 181 adults with diabetic polyneuropathy took 600, 1,200 or 1,800 mg a day or placebo for five weeks. Foot symptom scores (stabbing pain, burning, pins and needles, numbness) fell by about half in every lipoic acid group and by about a third on placebo; the authors judged 600 mg the best balance, since nausea, vomiting and vertigo rose with dose ^[1]. A 2023 meta-analysis of ten oral trials (1,242 patients) found better symptom scores with a dose-related trend, but no clear benefit on nerve conduction or vibration tests ^[3]. The four-year NATHAN 1 trial (460 patients, 600 mg a day) missed its main composite goal, while some secondary impairment scores favored lipoic acid ^[2]. Much of the older positive evidence came from 600 mg given by intravenous drip, which is a different situation from a capsule ^[4].

For Arialief, the takeaway is simple. The research points to about 600 mg by mouth, and this capsule cannot hold that.

L-carnitine: the studied form is different

The nerve research is on acetyl-L-carnitine, a related but distinct compound. Arialief lists plain L-carnitine. A Cochrane review of four trials (907 participants) rated the evidence for pain as very low certainty: doses of 1,500 mg a day or less looked no different from placebo, and the reviewers were very uncertain about any benefit at all ^[5]. A form that was not studied, at an undisclosed share of a 575 mg blend, gives us nothing to compare.

Coenzyme Q10: one small trial at a large dose

In a 12-week trial of 49 adults with type 2 diabetes and polyneuropathy, 400 mg of ubiquinone a day improved symptom and impairment scores and some nerve conduction measures compared with placebo ^[6]. That is a single small study, and 400 mg is most of Arialief's entire blend weight. The sales page also says coenzyme Q10 "quickly" penetrates damaged nerves and restores their function. We found no human study showing that.

Turmeric: mixed results, different form

Two Iranian trials tested 80 mg a day of nano-curcumin, a form designed to be absorbed better than ordinary extracts. The first (80 patients, 8 weeks) reported lower neuropathy scores than placebo ^[7]. The second, larger and longer (97 randomized, 16 weeks), found no difference in pain or nerve scores ^[8]. Arialief uses a standard 95% curcuminoid extract, which is not the studied form.

Butcher's broom and magnesium: supporting roles at best

Butcher's broom has one solid placebo-controlled trial, in 166 women with chronic venous insufficiency, where it reduced leg volume and heaviness over 12 weeks ^[9]. It was a leg circulation study with no nerve outcomes. For magnesium, a systematic review of nine trials in chronic pain, including three small neuropathic pain studies, called the evidence equivocal and could not pool the results ^[10]. Eighty milligrams of a well-absorbed form is a reasonable everyday top-up, and it is the one dose on this label you can actually see.

What the marketing claims and what we could verify

• "The key ingredient, palmitoylethanolamide (PEA)." The FAQ on both versions of the sales page calls PEA the key ingredient and pairs it with "turmeric extract." PEA does not appear on the Supplement Facts label or in the ingredient section of the same page. PEA does have its own pain research ^[11], which makes the mismatch more confusing for a buyer, not less. We treat the label as what is in the bottle.
• "Research-backed formula." The site's reference page lists eight items. Two are about magnesium and testosterone; the rest are general papers on nerve pain and how it is treated. None tests Arialief or this blend.
• "No side effects" and "you can take Arialief even if you're currently using other medications." The trials above report side effects such as nausea with lipoic acid ^[1], and the safety section below lists real interaction concerns. Arialief's own label warns users to consult a physician, "especially if you are taking a medication." The label is the more careful document, and we side with it.
• Leftover copy. One comparison block on the page promises "superior blood sugar support," which has nothing to do with this formula. Shipping times are also given two ways (7 to 14 business days in one answer, 5 to 7 days in another).

Price, packages and refund policy

One bottle lasts 30 days. Prices on arialief.com when we checked:

• 6 bottles: $49 each ($294 total), free US shipping, four digital bonuses including a members area. About $1.63 a day.
• 3 bottles: $69 each ($207 total), free US shipping, one digital bonus.
• 2 bottles: $79 each ($158 total), shipping extra.

There is no single-bottle option. The 60-day refund policy deserves a careful read before you order. Returns must include all bottles, empty or not, shipped within 7 days of receiving return instructions, and return postage is on you unless the order arrived wrong or damaged. The refund covers the product price. The policy also says "bulk or reseller orders are not eligible" without defining bulk, and the page variously counts the 60 days from purchase and from delivery. If you buy, ask support in writing how a 6-bottle order is treated.

One more thing to say plainly: Stark Verve has no affiliate relationship with the seller of Arialief and earns nothing if you buy it. The buttons on this page go straight to the official site without tracking.

Safety

Results vary, and a supplement can interact with what you already take. Points worth raising with your doctor, ingredient by ingredient:

• Alpha lipoic acid and blood sugar. Lipoic acid has been linked in case reports to insulin autoimmune syndrome, a rare cause of low blood sugar episodes ^[12]. If you take insulin or other glucose-lowering medicine, check with your doctor and watch your readings.
• Turmeric and the liver. The US Drug-Induced Liver Injury Network has documented cases of serious liver injury tied to turmeric products, typically one to four months after starting ^[13]. Stop and seek care if you notice dark urine, yellowing skin or eyes, or unusual fatigue.
• Coenzyme Q10 and warfarin. Case reports describe a weaker warfarin response with coenzyme Q10 ^[14], while a small crossover trial at 100 mg a day found no change in warfarin dose ^[15]. Anyone on a blood thinner should still tell the clinic that manages it before adding this product.
• Magnesium. If you have kidney disease, ask before taking any magnesium supplement.

Because the individual doses are hidden, neither you nor your doctor can judge exactly how much of each you would be taking. That is a safety cost of proprietary blends, on top of the value question.

What we liked and what gave us pause

Frequently asked questions

Where is Arialief sold?

On arialief.com, which runs its own checkout, and on a ClickBank-processed copy of the sales page. Its affiliate terms forbid promotion on marketplaces such as Amazon and eBay, so listings there may not be covered by the refund policy.

How much alpha lipoic acid is in Arialief?

The label does not say. Based on the blend weight it must be well below the 600 mg used in the main oral trials, and likely far below it.

Does Arialief contain PEA?

Not according to the Supplement Facts label we read. The FAQ on the sales page says it does. Ask the seller to clarify before buying if PEA is the reason you are interested.

How long before I notice anything?

Results vary. The trials of these ingredients ran from five weeks to four years, at doses this capsule does not reach, so the research cannot tell you what to expect from Arialief itself.

Can it replace my medication?

No. It is a dietary supplement. Do not stop or change a prescription without your doctor.

How we reviewed Arialief

We read both versions of the official sales page, the Supplement Facts label, the refund policy, the site's reference list and the vendor's affiliate terms. We searched PubMed for human trials of each ingredient on nerve symptoms and compared the doses used with what the label allows. We did not test the product on people, and nobody at Stark Verve is a medical professional. Read our editorial policy to see how we choose and update reviews. We are not affiliated with the seller of Arialief.